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Research Paper|Volume 12, Issue 11|pp 10211—10222

Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency

Yigit Cakiroglu1,4, Ayse Saltik1, Aysen Yuceturk1, Ozge Karaosmanoglu1, Sule Yildirim Kopuk1, Richard T. Scott Jr.2,3, Bulent Tiras1,4, Emre Seli2,5
  • 1Acibadem Maslak Hospital Assisted Reproductive Technologies Unit, Istanbul, Turkey
  • 2IVI RMA New Jersey, Basking Ridge, NJ 07920, USA
  • 3Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, PA 19107, USA
  • 4Acibadem University, Istanbul, Turkey
  • 5Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USA
Received: January 30, 2020Accepted: May 25, 2020Published: June 5, 2020
https://doi.org/10.18632/aging.103403

Copyright © 2020 Cakiroglu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We aimed to determine whether intraovarian injection of autologous platelet rich plasma (PRP) improves response to ovarian stimulation and in vitro fertilization (IVF) outcome in women with primary ovarian insufficiency (POI). Women (N=311; age 24-40) diagnosed with POI based on ESHRE criteria underwent intraovarian PRP injection. Markers of ovarian reserve, and IVF outcome parameters were followed. PRP treatment resulted in increased antral follicle count (AFC) and serum antimullerian hormone (AMH), while serum follicle stimulating hormone (FSH) did not change significantly. After PRP injection, 23 women (7.4%) conceived spontaneously, 201 (64.8%) developed antral follicle(s) and attempted IVF, and 87 (27.8%) had no antral follicles and therefore did not receive additional treatment. Among the 201 women who attempted IVF, 82 (26.4% of total) developed embryos; 25 of these women preferred to cryopreserve embryos for transfer at a later stage, while 57 underwent embryo transfer resulting in 13 pregnancies (22.8% per transfer, 4% of total). In total, of the 311 women treated with PRP, 25 (8.0%) achieved livebirth/sustained implantation (spontaneously or after IVF), while another 25 (8.0%) cryopreserved embryos. Our findings suggest that in women with POI, intraovarian injection of autologous PRP might be considered as an alternative experimental treatment option.