Research Paper Volume 12, Issue 1 pp 309—317
Changes in sleep duration and 3-year risk of mild cognitive impairment in Chinese older adults
- 1 Department of Preventive Medicine, North Sichuan Medical College, Nanchong, China
- 2 Institute of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, China
- 3 Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China
Received: August 20, 2019 Accepted: December 5, 2019 Published: January 3, 2020
https://doi.org/10.18632/aging.102616How to Cite
Abstract
Objective: This study aimed to determine whether changes in sleep duration are associated with a higher risk of mild cognitive impairment (MCI) in older adults.
Results: By the 3-year follow-up, 592 participants developed MCI. Compared with the individuals who had an unchanged sleep duration, the odds ratio (95% confidence interval) for MCI was 1.44 (1.08-1.91) for those whose sleep duration increased by ≥2 h after multivariate adjustments. Moreover, changing from a long to moderate, but not short, sleep duration was negatively associated with the incidence of MCI (odds ratio: 0.65; 95% confidence interval, 0.45-0.93).
Conclusions: These findings suggest that increased sleep duration is associated with a higher risk of MCI in the elderly. Furthermore, a moderate duration of sleep (6-9 h) could serve as a possible strategy for prevention of MCI.
Methods: This longitudinal study was conducted with a nationally representative sample of 5419 older Chinese adults (≥65 years) from the 2008 and 2011 waves of the Chinese Longitudinal Healthy Longevity Survey. Sleep duration was assessed by a self-administered questionnaire. MCI was defined according to the Mini-Mental State Examination. An adjusted logistic regression model was used to explore the associations between changes in sleep duration and MCI.
Abbreviations
MCI: mild cognitive impairment; CLHLS: Chinese Longitudinal Healthy Longevity Survey; ADL: activities of daily living; BMI: body mass index; MMSE: Mini-Mental State Examination; OR: odds ratio; CI: confidence interval; ANOVA: analysis of variance.