Research Paper Volume 11, Issue 23 pp 11490—11503
Conditional disease-free survival in high-risk renal cell carcinoma treated with sunitinib
- 1 Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
- 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Received: September 13, 2019 Accepted: November 19, 2019 Published: December 11, 2019
https://doi.org/10.18632/aging.102549How to Cite
Copyright © 2019 Shao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Disease-free survival (DFS) did not reflect accurate individual prognosis after initial diagnosis. As conditional DFS (CDFS) could provide dynamic prognostic information, we evaluated CDFS in these patients treated with or without sunitinib.
Results: A total of 1329 patients with median follow-up 6.54 years were enrolled. CDFS improved continuously with disease-free survivorship increasing in both sunitinib and placebo group with minimal difference. In placebo arm, the CDFS of surviving to five year after living 1, 2, 3, and 4 years were 65%, 78%, 87%, and 95% (observed 5-year DFS: 51%). Dynamic changes of HR showed adjuvant sunitinib decrease relapse risks during the first 1.5 years after surgery (P < 0.03).
Conclusions: Our study provided contemporary data of CDFS and change of relapse HR in high-risk ccRCC patients after adjuvant sunitinib or placebo. The remarkable improvement in CDFS highlighted the importance of disease-free interval as a strong indicator in patient counseling and surveillance planning.
Materials and Methods: The primary end point was CDFS and the second end point was smooth hazard ratios (HR) for the prediction of relapses. The differences of conditional survival were compared with the calculation of d value.