Review|Volume 11, Issue 23|pp 11756—11769

Adipose-derived stem cells contribute to cardiovascular remodeling

Hui Ni¹, Yiming Zhao², Yongli Ji¹, Jian Shen¹, Meixiang Xiang¹, Yao Xie¹

¹Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Endocrinology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

* Equal contribution

Received: May 14, 2019Accepted: November 17, 2019Published: December 4, 2019

Copyright © 2019 Ni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Obesity is an independent risk factor for cardiovascular disease. Adipose tissue was initially thought to be involved in metabolism through paracrine. Recent researches discovered mesenchymal stem cells inside adipose tissue which could differentiate into vascular lineages in vitro and in vivo, participating vascular remodeling. However, there were few researches focusing on distinct characteristics and functions of adipose-derived stem cells (ADSCs) from different regions. This is the first comprehensive review demonstrating the variances of ADSCs from the perspective of their origins.