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Research Paper|Volume 11, Issue 16|pp 6109—6119

Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease

Cuihua Zou1, Jie Wang2, Xiaohua Huang1, Chongdong Jian1, Donghua Zou3, Xuebin Li1
  • 1Department of Neurology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, People’s Republic of China
  • 2Department of Nephrology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, People’s Republic of China
  • 3Department of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 533022, People’s Republic of China
* Equal contribution
Received: May 18, 2019Accepted: August 5, 2019Published: August 16, 2019
https://doi.org/10.18632/aging.102169

Copyright © 2019 Zou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that ranks as the fourth most common cause of death in developed countries. In our study, genes differentially expressed between AD and healthy individuals were identified and used to construct protein-protein interaction (PPI) networks. The AD-related PPI network was used to identify functional modules, and enrichment analysis showed that they were significantly involved in “Alzheimer’s disease”, “apoptosis”, and related pathways. We predicted non-coding RNAs and transcription factors that may regulate the functional modules. The expression of hub genes and transcription factors was validated in an independent data set. The results in this study provide several candidates for further research on mechanisms of AD pathogenesis.