Research Paper Volume 11, Issue 14 pp 5058—5069
miR-548d-3p inhibits osteosarcoma by downregulating KRAS
- 1 Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110001, People’s Republic of China
Received: January 22, 2019 Accepted: July 11, 2019 Published: July 21, 2019
https://doi.org/10.18632/aging.102097How to Cite
Copyright © 2019 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
MicroRNAs (miRNAs) are known to be associated with certain cancers, including osteosarcoma. We examined osteosarcoma tissues and cell lines, and found that most expressed lower levels of miR-548d-3p than adjacent tissues and normal cell lines. KRAS was identified as a potential target gene of miR-548d-3p. In osteosarcoma cells, miR-548d-3p exerted tumor-suppressive effects by downregulating KRAS. Functional assays revealed that miR-548d-3p mimics dramatically reduced cell growth and migration in vitro. These results suggest that miR-548d-3p mimics could be applied for osteosarcoma treatment.