Aging
Navigate
Submit an Article
Research Paper|Volume 11, Issue 14|pp 5058—5069

miR-548d-3p inhibits osteosarcoma by downregulating KRAS

Jianhua Chen1, Chongnan Yan1, Honghao Yu1, Shihan Zhen1, Quan Yuan1
  • 1Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110001, People’s Republic of China
Received: January 22, 2019Accepted: July 11, 2019Published: July 21, 2019
https://doi.org/10.18632/aging.102097

Copyright © 2019 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

MicroRNAs (miRNAs) are known to be associated with certain cancers, including osteosarcoma. We examined osteosarcoma tissues and cell lines, and found that most expressed lower levels of miR-548d-3p than adjacent tissues and normal cell lines. KRAS was identified as a potential target gene of miR-548d-3p. In osteosarcoma cells, miR-548d-3p exerted tumor-suppressive effects by downregulating KRAS. Functional assays revealed that miR-548d-3p mimics dramatically reduced cell growth and migration in vitro. These results suggest that miR-548d-3p mimics could be applied for osteosarcoma treatment.