Research Paper Volume 10, Issue 11 pp 3089—3103
Glucose negatively affects Nrf2/SKN-1-mediated innate immunity in C. elegans
- 1 Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China
- 2 Department of Laboratory Medicine, Xiangya Medical School, Central South University, Changsh, Changsha 410013, China
- 3 Xinxiang Medical University, Hongqi District, 453003 Xinxiang, China
- 4 Forevertek Biotechnology Co.,Ltd, Building M0, Oversea Graduate Park National High-tech Industrial Zone, Changsha 10003, China
- 5 BGI-Shenzhen, BeiShan Industrial Zone, Yantian District, Shenzhen, Guangdong 518083, China
Received: June 5, 2018 Accepted: October 19, 2018 Published: November 15, 2018
https://doi.org/10.18632/aging.101610How to Cite
Abstract
High glucose levels negatively affect immune response. However, the underlying mechanisms are not well understood. Upon infection, the round worm C. elegans induces multiple gene transcription programs, including the Nrf2/SKN-1-mediated detoxification program, to activate the innate immunity. In this study, we find that high glucose conditions inhibit the SKN-1-mediated immune response to Salmonella typhimurium, exacerbate the infection and greatly decrease survival. The effect of glucose shows specificity to SKN-1 pathway, as UPRmit and UPRER that are known to be induced by infection, are not affected. Hyper-activation of SKN-1 by wdr-23 RNAi restores partly the immune response and increases the survival rate in response to S. typhimurium. In all, our study reveals a molecular pathway responsible for glucose’s negative effect on innate immunity, which could help to better understand diseases associated with hyperglycemia.