Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in
Yme U. van der Velden1,
,
Anna-Pavlina G. Haramis
,
-
1 Department of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands
Received: April 12, 2011
Accepted: April 25, 2011
Published: April 26, 2011
https://doi.org/10.18632/aging.100319
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van der Velden YU, Haramis AG, . Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in. Aging (Albany NY). 2011 Apr 26;
3:363-367
.
https://doi.org/10.18632/aging.100319
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Citation & Abstract
Copyright: © 2011 van der Velden et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy-metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue-specific and context-dependent effectors.
