Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
Alexey Moskalev1,
,
Mikhail Shaposhnikov
,
-
1 Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia
Received: March 24, 2011
Accepted: March 27, 2011
Published: March 28, 2011
https://doi.org/10.18632/aging.100314
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Moskalev A, Shaposhnikov M, . Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster. Aging (Albany NY). 2011 Mar 28;
3:391-394
.
https://doi.org/10.18632/aging.100314
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Citation & Abstract
Copyright: © 2011 Moskalev et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.
