Research Paper|Volume 3, Issue 4|pp 391—394

Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

Alexey Moskalev¹, Mikhail Shaposhnikov

¹Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia

Received: March 24, 2011Accepted: March 27, 2011Published: March 28, 2011

Copyright: © 2011 Moskalev et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.