Research Perspective Volume 3, Issue 2 pp 162—167
SirT1 brings stemness closer to cancer and aging
- 1 Department of Immunology and Oncology, Centro Nacional Biotecnología/CSIC, Cantoblanco, Madrid E-28049, Spain
- 2 Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA/HUCA), Universidad de Oviedo, 33006 Oviedo, Spain
Received: January 19, 2011 Accepted: February 7, 2011 Published: February 9, 2011
https://doi.org/10.18632/aging.100272How to Cite
Abstract
Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin activation for anti-aging therapy.