Research Perspective Volume 2, Issue 10 pp 735—741
Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
- 1 Division of Molecular Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Received: October 6, 2010 Accepted: October 16, 2010 Published: October 17, 2010
https://doi.org/10.18632/aging.100209How to Cite
Abstract
The epithelial-mesenchymal transition is involved in several physiological processes. However, it is also believed to contribute to cancer progression. Conversely, cellular senescence constitutes a failsafe program against cancer progression. Interestingly, EMT and senescence seem to cross paths, with several factors playing dominant roles in both settings. Here, we describe recent observations that link these important cellular processes.