Research Perspective|Volume 2, Issue 9|pp 612—620

Joint influence of small-effect genetic variants on human longevity

Anatoliy I. Yashin^1,², Deqing Wu¹, Konstantin G. Arbeev¹, Svetlana V. Ukraintseva^1,²

¹Center for Population Health and Aging, Duke University, Durham, NC 27708-0408, USA
²Duke Comprehensive Cancer Center, Duke University, Durham, NC 27708-0408, USA

Received: August 9, 2010Accepted: August 25, 2010Published: August 26, 2010

Copyright: © 2010 Yashin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The results of genome-wide association studies of complex traits, such as life span or age at onset of chronic disease, suggest that such traits are typically affected by a large number of small-effect alleles. Individually such alleles have little predictive values, therefore they were usually excluded from further analyses. The results of our study strongly suggest that the alleles with small individual effects on longevity may jointly influence life span so that the resulting influence can be both substantial and significant. We show that this joint influence can be described by a relatively simple “genetic dose - phenotypic response” relationship.