p53, ROS and senescence in the control of aging

Arnaud Vigneron¹, Karen H. Vousden

¹The Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK

Received: August 10, 2010Accepted: August 15, 2010Published: August 16, 2010

Copyright: © 2010 Vigneron et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Abstract: In addition to its function as a tumour suppressor, p53 is also involved in an increasing number of pathology associated with aging. Several activities of p53 appear contribute to its role in aging; one function that might be particularly relevant in this context is the regulation of senescence. The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.