Research Perspective Volume 2, Issue 8 pp 514—518
P66SHC and Ageing: ROS and TOR?
- 1 Institute of General Pathology, Universita' Cattolica Medical School, Rome Italy
Received: July 24, 2010 Accepted: July 27, 2010 Published: July 28, 2010
https://doi.org/10.18632/aging.100182How to Cite
Abstract
Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.