Research Perspective|Volume 2, Issue 8|pp 514—518

P66SHC and Ageing: ROS and TOR?

Giovambattista Pani¹

¹Institute of General Pathology, Universita' Cattolica Medical School, Rome Italy

Received: July 24, 2010Accepted: July 27, 2010Published: July 28, 2010

Copyright: © 2010 Pani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.