Review|Volume 1, Issue 6|pp 503—510

P66Shc signals to age

Mirella Trinei¹, Ina Berniakovich², Elena Beltrami², Enrica Migliaccio², Ambrogio Fassina³, PierGiuseppe Pelicci², Marco Giorgio²

¹Congenia Srl, 20139 Milan, Italy
²Department of Experimental Oncology, European Institute of Oncology, 20139 Milan, Italy
³Department of Oncological and Surgical Sciences, Pathology Section, Cytophatology Unit, 35100 Padua, Italy

Received: May 7, 2009Accepted: June 4, 2009Published: June 5, 2009

https://doi.org/10.18632/aging.100057

Copyright: © 2009 Trinei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66^Shc, a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.