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• Research PaperVolume 12, Issue 7pp 6151-6171

  Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

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  Valérie Fontaine, Elodie Monteiro, Mylène Fournié, Elena Brazhnikova, Thinhinane Boumedine, Cécile Vidal, Christine Balducci, Louis Guibout, Mathilde Latil, Pierre J. Dilda, Stanislas Veillet, José-Alain Sahel, René Lafont, Serge Camelo

  Keywords: norbixin, retinal function, A2E, AMD, Stargardt disease

  Published in Aging on April 7, 2020

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• Research PaperVolume 13, Issue 18pp 22040-22058

  A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin

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  Valérie Fontaine, Mylène Fournié, Elodie Monteiro, Thinhinane Boumedine, Christine Balducci, Louis Guibout, Mathilde Latil, José-Alain Sahel, Stanislas Veillet, Pierre J. Dilda, René Lafont, Serge Camelo

  Keywords: N-retinylidene-N-retinylethanolamine (A2E), norbixin, peroxisome proliferator-activated receptor (PPAR), retinal pigment epithelium (RPE), retinoic X receptor (RXR)

  Published in Aging on September 20, 2021

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