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Volume 17, Issue 9

September 30, 2025pp 2241—2451

About the Cover

The cover features Figure 4 "Acute effects of OT+A5i on de novo systemic proteomes of males and females" from Conboy et al.

Research Perspective

Analysis of the current state of frailty indexes and their implementation for aging intervention studies

Oliver G. Frost, Anna Barkovskaya, Michael J. Rae, Marcela Atzori, Abdelhadi Rebbaa, Amit Sharma

https://doi.org/10.18632/aging.206307pp 2241—2251
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Research Papers

Sex-specific longitudinal reversal of aging in old frail mice

Cameron Kato, Jessica Zheng, Cindy Quang, Sophia Siopack, Joana Cruz, Zachery R. Robinson, Nicole Fong, Zhixin A. Zhang, Patrick Young, Michael J. Conboy, Irina M. Conboy

https://doi.org/10.18632/aging.206304pp 2252—2277
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Deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome: implications for adipogenesis

Felix Quirin Fenzl, Eva-Maria Lederer, Louisa Brumma, Peter Krüger, Moritz Schroll, Frederic Wilming, Karima Djabali

https://doi.org/10.18632/aging.206309pp 2278—2311
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The impact of long-term social housing on biconditional association task performance and neuron ensembles in the anterior cingulate cortex and the hippocampal CA3 region of aged rats

Anne M. Dankert, Abbi R. Hernandez, Taylor B. Wise, Katrina I. T. Dayaw, Judith N. T. Dayaw, Rachael M. Layden, Katelyn N. Lubke, Sara N. Burke, Victoria L. Templer

https://doi.org/10.18632/aging.206310pp 2312—2334
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Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity

Daniel R. Machin, Md. Torikul Islam, Alec Malouf, Daniel Nguyen, Mostafa Sabouri, Maryana Boulos, Andrew G. Horn, Kiana M. Schulze, Gwenael Layec, Lisa A. Lesniewski, Anthony J. Donato

https://doi.org/10.18632/aging.206313pp 2335—2350
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Runx1 overexpression induces early onset of intervertebral disc degeneration

Takanori Fukunaga, Martha Elena Diaz-Hernandez, John G. Heller, Changli Zhang, Hicham Drissi

https://doi.org/10.18632/aging.206316pp 2369—2391
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Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice

Takashi Ohira, Naoyuki Kawao, Yuya Mizukami, Kiyotaka Okada, Akihito Nishikawa, Hisatoshi Yamao, Ayaka Yamada, Hiroshi Kaji

https://doi.org/10.18632/aging.206318pp 2392—2409
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Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles

Jessica Louzame Ruano, Leire Bejarano, Rosa Serrano, Ruth Alvarez Diaz, Juana Maria Flores, Ana Cayuela López, Maria A. Blasco

https://doi.org/10.18632/aging.206320pp 2410—2429
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Review

Mitochondrial proteins as biomarkers of cellular senescence and age-associated diseases

Anna Panfilova, Tatiana Zubareva, Ekaterina Mironova, Gianluigi Mazzoccoli, Maria Greta Pia Marasco, Sofya Balazovskaia, Peter Yablonsky, Igor Kvetnoy

https://doi.org/10.18632/aging.206305pp 2430—2448
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