Volume 17, Issue 5

May 30, 2025pp 1077—1370

About the Cover

The cover features Figure 1 "Hypoxia-induced cerebrovascular remodeling is triggered at a higher O₂ level in aged mice" from Sapkota et al.

Editorial

Rethinking healthcare through aging biology

Marco Demaria

https://doi.org/10.18632/aging.206262pp 1077—1079

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Letter to the Editor

Dietary polyphenol assessment for aging research

Ryan Bradley, Kara Fitzgerald, Romilly Hodges, Jamie L. Villanueva

https://doi.org/10.18632/aging.206252pp 1080—1081

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Research Perspective

Methylation clocks for evaluation of anti-aging interventions

Josh Mitteldorf

https://doi.org/10.18632/aging.206245pp 1082—1090

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Research Papers

Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age

Arjun Sapkota, Sebok K. Halder, Richard Milner

https://doi.org/10.18632/aging.206241pp 1091—1104

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APOE genotype and biological age impact inter-omic associations related to bioenergetics

Dylan Ellis, Kengo Watanabe, Tomasz Wilmanski, Michael S. Lustgarten, Andres V. Ardisson Korat, Gwênlyn Glusman, Jennifer Hadlock, Oliver Fiehn, Paola Sebastiani, Nathan D. Price, Leroy Hood, Andrew T. Magis, Simon J. Evans, Lance Pflieger, Jennifer C. Lovejoy, Sean M. Gibbons, Cory C. Funk, Priyanka Baloni, Noa Rappaport

https://doi.org/10.18632/aging.206243pp 1105—1138

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Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets

Kasumi Hattori, Masaru Shimizu, Megumi Yamachi, Kiichi Tezuka, Toru Fukushima, Syoko Yokota, Tatsuya Okano, Shingen Misaka, Shizu Hidema, Kazuaki Kanai, Kenju Shimomura, Yuko Maejima

https://doi.org/10.18632/aging.206244pp 1139—1147

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Frailty transitions in electronic health records: who first? what first?

Fabienne Hershkowitz Sikron, Rony Schenker, Orit Shahar, Achinoam Ben Akiva-Maliniak, Galit Segal, Yishay Koom, Idit Wolf, Bawkat Mazengya, Maor Lewis, Tzippy Shochat, Dov Albukrek

https://doi.org/10.18632/aging.206247pp 1148—1163

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Short-term moderate caloric restriction in the rhesus macaque attenuates markers of ovarian aging in select populations

Emma S. Gargus, Rhea Sharma, Rebecca Gu, Camille Mulcahy, Brian W. Johnson, Jing Song, Jungwha Lee, Mary Zelinski, Francesca E. Duncan

https://doi.org/10.18632/aging.206253pp 1164—1189

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Investigating telomere length in progeroid syndromes: implications for aging disorders

Luma Srour, Abeer Qannan, Junko Oshima, Andre Megarbane, Yosra Bejaoui, Nady El Hajj

https://doi.org/10.18632/aging.206255pp 1190—1205

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Changes in metabolism-related RNA expression in circulating white blood cells of aged individual with physical frailty

Yuka Okinaka, Yoshihito Suda, Tomoyuki Matsumoto, Ryosuke Kuroda, Yoshiyuki Shinagawa, Sheraz Gul, Carsten Claussen, Ikuko Matsui, Yutaka Matsui, Akihiko Taguchi

https://doi.org/10.18632/aging.206256pp 1206—1220

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Methods for joint modeling of longitudinal omics data and time-to-event outcomes: applications to lysophosphatidylcholines in connection to aging and mortality in the Long Life Family Study

Konstantin G. Arbeev, Olivia Bagley, Svetlana V. Ukraintseva, Alexander Kulminski, Eric Stallard, Michaela Schwaiger-Haber, Gary J. Patti, Yian Gu, Anatoliy I. Yashin, Michael A. Province

https://doi.org/10.18632/aging.206259pp 1221—1260

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Role of apolipoprotein E (ApoE) ε4 in cognitive impairment after a stroke: a prospective cohort study

Jia-Hung Chen, Lung Chan, Chien-Tai Hong, Chaur-Jong Hu, Yi-Chen Hsieh

https://doi.org/10.18632/aging.206248pp 1261—1274

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Cisd1 synergizes with Cisd2 to modulate protein processing by maintaining mitochondrial and ER homeostasis

Yi-Fan Chen, Yuan-Chi Teng, Jian-Hsin Yang, Cheng-Heng Kao, Ting-Fen Tsai

https://doi.org/10.18632/aging.206249pp 1275—1297

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The aspartate superpathway in gut microbiota-related metabolic pathways mediates immune cell protection against COPD and IPF: a Mendelian randomization analysis

Lei Chen, Haoyan Chen, Qin Li, Jun Ma, Yanzhi Feng, Shenghua Zhang, Yu Han, Jie Pan, Mingjiong Zhang, Kai Sun, Shuangshuang Wu

https://doi.org/10.18632/aging.206250pp 1298—1312

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Updated efficacy and safety of CDK4/6 inhibitors plus endocrine therapy in elderly women with HR+/HER-2 metastatic or advanced breast cancer: patient-level network meta-analysis

Henry WC Leung, Mei-Ching Tsai, Shin-Hang Leung, Shyh-Yau Wang, Agnes LF Chan

https://doi.org/10.18632/aging.206257pp 1313—1327

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Clinical Research Protocol

Update on the detection of frailty in older adults: a multicenter cohort machine learning-based study protocol

Samuel Fernández-Carnero, Oliver Martínez-Pozas, Daniel Pecos-Martín, Armando Pardo-Gómez, Juan Nicolás Cuenca-Zaldívar, Eleuterio A. Sánchez-Romero

https://doi.org/10.18632/aging.206254pp 1328—1339

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Review

Age-associated changes in the heart: implications for COVID-19 therapies

Colby Wood, Wm. Zachary Salter, Isaiah Garcia, Michelle Nguyen, Andres Rios, Jacqui Oropeza, Destiny Ugwa, Upasana Mukherjee, Ujala Sehar, P. Hemachandra Reddy

https://doi.org/10.18632/aging.206251pp 1340—1367

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Corrections

Correction for: EpiAge: a next-generation sequencing-based ELOVL2 epigenetic clock for biological age assessment in saliva and blood across health and disease

David Cheishvili, Sonia Do Carmo, Filippo Caraci, Margherita Grasso, A Claudio Cuello, Moshe Szyf

https://doi.org/10.18632/aging.206263pp 1368

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Correction for: D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway

Xingxing Xu, Xiya Shen, Wenjin Feng, Danlu Yang, Lingting Jin, Jiaojiao Wang, Mianxian Wang, Zhang Ting, Feng Xue, Jingjing Zhang, Chaobo Meng, Roumeng Chen, Xinru Zheng, Leilei Du, Lina Xuan, Ying Wang, Tian Xie, Zhihui Huang

https://doi.org/10.18632/aging.206264pp 1369—1370

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