Figure 9.Schematic illustration of our hypothesis that links RNA transcription in WBC and physical frailty. Direct cell-cell interaction between circulating WBC and endothelium/satellite cells in healthy aged individuals decreases RNA transcription of metabolic-related genes in WBC while maintaining muscle function (A). In contrast, impaired cell-cell interactions result in no changes in the RNA transcription of metabolic-related genes in WBC, with impaired maintenance of muscle function (B).
