Research Paper

Figure 1. Study design to identify APOE genotype- and delta age-related alterations in the metabolome and inter-omic associations. Community dwelling individuals from the Arivale cohort were sorted based on delta age and APOE ε2 or ε4 carrier status. Metabolomic changes across APOE and delta age statuses were then analyzed. Finally, an inter-omic interaction analysis was performed to identify the effect modification of APOE or delta age status on inter-omic associations. These findings elucidate potential context-dependent relationships within APOE status and delta age group. Analyses were then repeated for validation with the TwinsUK cohort.