Proteomic and secretomic comparison of young and aged dermal fibroblasts highlights cytoskeleton as a key component during aging

Fran&#xe7;oise Boismal; Sandy Peltier; Sophie Ly ka so; Guillaume Chevreux; Lo&#xef;se Blondel; K&#xe9;vin Serror; Niclas Setterblab; Elina Zuelgaray; David Boccara; Maurice Mimoun; Christelle Guere; Armand Benssussan; Marie Dorr; Gallic Beauchef; Katell Vie; Laurence Michel

doi:doi:10.18632/aging.206055

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Research Paper Volume 16, Issue 16 pp 11776—11795

Proteomic and secretomic comparison of young and aged dermal fibroblasts highlights cytoskeleton as a key component during aging

Figure 2. Quiescence and TGF-β₁-stimulated PROTEOME heat-map and schematic representations of molecular pathways. (A) Heat-maps of differentially-expressed proteins in young and old fibroblasts (n=6) (HeatMapper). (B) Analysis of cellular processes linked to differentially-expressed proteins (GOrilla and Panthere). (C) Representation of signaling pathways and links between differentially-expressed proteins in quiescence and (D) TGF-β₁-treated condition (PathVisio).