Research Paper Volume 16, Issue 14 pp 11339—11358
PART1 facilitates tumorigenesis and inhibits ferroptosis by regulating the miR-490-3p/SLC7A11 axis in hepatocellular carcinoma
Figure 1. The prognostic ferroptosis-associated lncRNA-based ceRNA network in HCC. (A) Differentially expressed ferroptosis-associated genes in HCC. (B) Kaplan-Meier survival analysis for SCL7A11 in HCC patients. (C) The prognostic ferroptosis-associated ceRNA regulatory network based on lncRNA in HCC. Ellipse: LncRNA, diamond: miRNA, hexagon: mRNA, dark colors indicate up-regulated expressions and light colors indicate down-regulated expressions. (D) Correlation of miRNA-490-3p with the expression of PART1 and SLC7A11. (E–G) Relative expression of PART1, miRNA-490-3p, and SLC7A11 in HCC cell lines HCCLM and Huh7. (H–I) Kaplan-Meier survival analysis for PART1 and miRNA-490-3p in patients with HCC. (J) The PART1/miRNA/SLC7A11 axis in HCC derived from the ceRNA mechanism. *p < 0.05, **p < 0.01.