Research Paper Volume 16, Issue 12 pp 10203—10215
Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome
Figure 2. DS mice show a marked increase in liver inflammation. Western blot analysis on 12-months old Eu and Ts2Cje liver extracts against Hsp90, Hsp60, and Clpp (A). Ts2Cje mice showed a decreased Hsp90 (B), Hsp60 (C) levels, while Clpp accumulation is increased (D). GAPDH was used as housekeeping protein. Histograms are representative of four different experiments (*P ≤ 0.05; **P ≤ 0.01).