Research Paper Volume 16, Issue 12 pp 10512—10538
The crosstalk role of CDKN2A between tumor progression and cuproptosis resistance in colorectal cancer
Figure 9. CDKN2A enhances colorectal cancer cell viability and migration through suppressing cuproptosis. (A) Western blot analysis was performed to examine the expression changes of FDX1 in HT-29 and HCT116 cells following knockdown of CDKN2A and addition of a cuproptosis inhibitor (*P<0.05, **P<0.01, ***P<0.001). (B) The CCK8 assay was utilized to assess alterations in cell proliferation ability in HT-29 and HCT116 cells upon CDKN2A knockdown and cuproptosis inhibitor treatment (*P <0.05, **P <0.01, ***P <0.001). (C) Transwell assay was employed to evaluate changes in cell invasion ability in HT-29 and HCT116 cell lines following CDKN2A knockdown and cuproptosis inhibitor supplementation (*P <0.05, ** P <0.01, *** P <0.001).