Research Paper Volume 16, Issue 12 pp 10380—10401

Figure 3. Formononetin targeted genes related to immune responses in immune cells of prostate cancer. Gene Ontology (GO) enrichment analysis showed the biological roles of formononetin in (A) immune response, (B) interleukins and cytokines production, and (C) leukocyte of immune cell cluster of prostate cancer. (D) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed the roles of formononetin’s targets in apoptosis, and antigen presentation through the regulation of cell signaling pathways of immune cells. Lower panel of each figure was the Circos plot to show the involvement of gene in each item. The size of bubble represented the number of gene. The color of bubble represented the significance of the biological processes and pathways.