Research Paper Volume 16, Issue 11 pp 9558—9568
The protective effects of orexin-A in alleviating cell senescence against interleukin-1β (IL-1β) in chondrocytes
Figure 5. Treatment with orexin-A prevented IL-1β-induced activation of the p53/p21 axis. Cells were stimulated with IL-1β (10 ng/ml) with or without orexin-A (5 and 10 μM). (A) The levels of Acetyl-p53; (B) The mRNA levels of p21; (C) The protein levels of p21 (##P < 0.01 vs. vehicle group; ^, ^^P < 0.05, 0.01 vs. IL-1β group, n = 5).