Research Paper Volume 16, Issue 10 pp 9216—9227
The protective effects of Chromofungin in oligomeric amyloid β42 (Aβ42)-induced toxicity in neurons in Alzheimer’s disease
Figure 6. Chromofungin decreased the levels of COX-2 and the generation of PGE2 against oligomeric Aβ42 in M17 neuronal cells. Cells were incubated with oligomeric Aβ42 (5 μM) with or without Chromofungin (0.5, 1 mM) for 24 hours. (A) mRNA of COX-2 as measured by real-time PCR; (B) Protein expression of COX-2 as measured by western blot; (C) Production of PGE2 as measured by ELISA (n = 6, **P < 0.01 vs. vehicle group; †, ††P < 0.05, 0.01 vs. Aβ42 group).