Research Paper Volume 16, Issue 9 pp 8000—8018
A systematic pan-cancer analysis identifies LDHA as a novel predictor for immunological, prognostic, and immunotherapy resistance
Figure 10. Knockdown of LDHA inhibited proliferation and migration of LUAD. (A, B) Knockdown of LDHA was verified by RT-qPCR and western blot in NCI-H441 cells. (C) Microscopic observations were recorded at 0, 12, and 24 h after scratching the surface of a confluent layer of the indicated NCI-H441 cells. (D, E) MTT assay suggested that knockdown of LDHA inhibited the proliferation of NCI-H441 cells. (F) The effects of LDHA on cell migration and invasion were examined by transwell assays in NCI-H441 cells. (G) Quantitative analysis of cell migration in NCI-H441 cells. (H) Quantitative analysis of cell invasion in NCI-H441 cells. *p < 0.05, **p < 0.01, ***p < 0.001.