Research Paper Volume 16, Issue 7 pp 6510—6520
has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway
Figure 5. hsa-miR-134-5p suppresses tumor growth in a nude mouse xenograft model by inhibiting BDNF. (A) The nude mice exhibit tumor growth and a significant reduction in tumor volume in both the miR134-mimics group and miR134-mimics plus BDNF-NC group compared to the NC group; however, it should be noted that hsa-miR-134-5p mimics plus BDNF-NC treatment increased in tumor volume. (B) Western blot results revealed that the levels of BDNF, cyclin D1, cyclin A2, MMP2/9, p-TrKB, and ERK1/2 were significantly higher in both the miR134-mimics group and miR134-mimics plus BDNF-NC group compared to the NC group. However, in the miR134-mimics plus BDNF-OE group, there was an increase observed in the expression levels of BDNF, cyclin D1, cyclin A2, MMP2/9 as well as p-TrKB and ERK1/2.