Research Paper Volume 16, Issue 7 pp 6488—6509

Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer

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Figure 1. High expression of TCF19 is associated with poor prognosis in thyroid cancer. (A) The expression pattern of TCF19 in total was analyzed in 512 THCA tissues and 59 normal controls (TCGA database). (B) Kaplan-Meier analysis evaluating the association between Progress Free Interval and TCF19 expression in thyroid cancer patients (N=512) in the TCGA-THCA cohort. Progress Free Interval analysis was further stratified by TCF19-High and TCF19-Low characteristics for Kaplan–Meier analysis. (C) The expression pattern of TCF19 in GSE29265 and GSE33630, comparing normal thyroid tissues with thyroid cancer. (DG) The relationship between TCF19 expression and T stage (D), N stage (E), M stage (F) and TNM stage (G) in TCGA cohort. (H) The expression pattern of TCF19 in 20 THCA tumor and their adjacent tissues. *p<0.05, **p < 0.01, ***p<0.001, NS, not significant.