Research Paper Volume 16, Issue 7 pp 6417—6444
Pan-cancer analysis of Sushi domain-containing protein 4 (SUSD4) and validated in colorectal cancer
Figure 7. Drug sensitivity analysis based on SUSD4 expression. (A) CTRP database and (B) GDSC database. (C) Venn diagram between two drug datasets. (D) Colorectal cancer organoids under a 4X microscope, the length of the bar is 100μM. (E) IC50 for three drugs in 12 organoids. (F) Spearman correlation between mRNA level of SUSD4 and IC50 of three drugs, the size and color of the dots represent IC50 and organoids’ ID respectively. CTRP, cancer therapeutics response portal. GSDC, genomics of drug sensitivity in cancer. IC50, half maximal inhibitory concentration. P-values were adjusted by false discovery rate (FDR) method.