Figure 3. Overview of the microarray signatures. (A) Box plots show the normalized intensities from the two groups. (B) Hierarchical clustering of all DECs with a fold-change ≥1.5 and p-value < 0.05. (C) CircRNAs in the Scatter-Plot located above the top green line and below the bottom green line indicated more than a 1.5-fold change of circRNAs. (D) Volcano plot filtering revealed that 80 DECs, including 1 up-regulated and 79 down-regulated circRNAs. Abbreviation: DECs: differentially expressed circRNAs.