Research Paper Volume 16, Issue 7 pp 6147—6162

Figure 9. Effects of Poria cocos polysaccharides (PCPs) on Nrf2 and ferroptosis-related signaling pathways in BLR3A cells. Compared with the control group, the levels of Nrf2, GSH, FTH1, HO-1, GPX4 in BLR3A cells were significantly reduced after the alcohol and ML385 intervention (P<0.05); after intervention with PCP (100 μg/mL), compared with the ALD group and the ALD+ML385 group, the expression of Nrf2, GSH, FTH1, HO-1, GPX4, and other mRNAs in rat BLR3A cells was significantly increased (P<0.05); after Fer-1 (100 μg/mL) intervention, the expression of Nrf2, GSH, FTH1, HO-1, and GPX4 in the rat liver tissue was significantly increased (P<0.05). The reported values are presented as mean ± SD, n = 3. ^*P<0.05, ^***P<0.01, compared with the control group; ^#P<0.05, ^###P<0.01, compared with the ALD group; ^x P<0.05, ^xxx P<0.01, compared with the ALD+ML385 group.