Research Paper Volume 16, Issue 7 pp 6147—6162

Figure 3. Effects of Poria cocos polysaccharides (PCPs) on oxidative stress and ferroptosis in alcoholic liver disease (ALD) rats. After the intervention of PCP (100 mg/kg), compared with the ALD group and the ALD+ML385 group, the malondialdehyde (MDA) and Fe²⁺ levels of the rats were significantly reduced (P<0.01), and superoxide dismutase (SOD) and glutathione (GSH) were significantly increased (P<0.01). After intervention with PCP as well as Fer-1, MDA and Fe²⁺ in rats were significantly reduced (P<0.01), and SOD (P<0.01) and GSH (P<0.05) were significantly increased, indicating that PCP can improve oxidative stress by regulating ferroptosis. The reported values are presented as mean ± SD, n = 8. ^*P<0.05, ^***P<0.01, compared with the control group. ^#P < 0.05, ^###P < 0.01, compared with the ALD group; ^xP < 0.05, ^xxxP < 0.01, compared with the ML385 group.