Research Paper Volume 16, Issue 7 pp 5929—5948

Figure 6. EIF3D influences the alternative splicing of genes in FaDu cells. (A) Bar plot displaying the number of all significantly regulated alternative splicing events (RASEs). The X-axis represents the RASE number, while the Y-axis represents the different types of AS events. "Up" indicates that the splicing pattern occurs in a higher proportion in the siEIF3D group than in the NC group, while "down" indicates the opposite. (B) Bubble diagram presenting the most enriched GO biological process results of RASGs. (C) Venn diagram illustrating the overlap in gene numbers between RASGs and DEGs. (D) Chord diagram demonstrating the co-expression of EIF3D with immune-associated RASGs. (E) Schematic diagrams depicting the structures of ASEs. RNA-seq validation of ASEs is displayed at the bottom of the right panel. Error bars represent mean ± SEM. ^*P-value < 0.05, ^**P-value < 0.01, ^***P-value < 0.001.