Research Paper Volume 16, Issue 7 pp 5929—5948
RNA splicing regulator EIF3D regulates the tumor microenvironment through immunogene-related alternative splicing in head and neck squamous cell carcinoma
Figure 2. Correlation between the EIF3D and the tumor microenvironment and immune checkpoint genes. (A) Correlation analysis of ImmuneScore, StromalScore, and ESTIMATEScore with EIF3D. (B) Box plots illustrating variations in immune cell infiltration proportions between high-EIF3D and low-EIF3D patient groups. (C) Lollipop graph depicting the correlation between immune infiltration and EIF3D. (D) Correlation analysis between EIF3D and immune checkpoint genes. (E–H) Evaluation of immunotherapy outcomes involving anti-CTLA4 and anti-PD1 inhibitors in EIF3D high and low expression groups. Error bars denote mean ± SEM. Significance levels: *P-value < 0.05, **P-value < 0.01, ***P-value < 0.001.