Research Paper Volume 16, Issue 7 pp 5916—5928
Downregulating miRNA-199a-5p exacerbates fluorouracil-induced cardiotoxicity by activating the ATF6 signaling pathway
Figure 6. miRNA-199a-5p attenuates 5-FU induced toxicity via ATF6 in vivo. (A) miRNA-199a-5p in heart tissue after exogenous introduced; (B) miRNA-199a-5p liposomes improves left ventricular developed pressure in 5-FU injured heart tissue. (C) miRNA-199a-5p liposome decreases LDH, increases SOD activity and the ratio of GSH/GSSG in injured cardiac tissues; (D) the pathological injuries in cardiac tissues caused by 5-FU ameliorated by miRNA-199a-5p liposome; (E) miRNA-199a-5p liposome treatment reduced ATF6 expression in injured cardiac tissues significantly. The expression of ATF6 was confirmed by immunohistochemistry analysis.