Research Paper Volume 16, Issue 6 pp 5703—5710
M1 intestinal macrophages-derived exosomes promote colitis progression and mucosal barrier injury
Figure 4. Suppressing TLR4 signal antagonizes M1-Exo. (A) DAI score (n = 10). DAI score of Res+M1-Exo group decreased relative to M1-Exo group. (B) Body weight measurement (n = 10). Weight loss of Res+M1-Exo group decreased relative to M1-Exo group. (C) Intestinal tissue length (n = 10). Res+M1-Exo group had apparently higher length than M1-Exo group. (D) FITC-D (n = 10). Res reduced mucosal barrier permeability, and FITC-D concentration of Res+M1-Exo group dramatically decreased relative to M1-Exo group. (E) Pathological score (n = 10). Res reduced the score, lower than that in M1-Exo group. (F–K) ELISA (n = 10). Res decreased inflammatory factor levels IFN-γ, IL-6, IL-1β and TNF-α, and elevated those of IL-10 and IL-13, with significant differences relative to M1-Exo group. *P < 0.05 versus Control group, #P < 0.05 versus DSS group.