Research Paper Volume 16, Issue 6 pp 5601—5617
WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma
Figure 8. Immune-related analysis. (A) Correlation between WTAP and immune score, stromal score, and tumor purity. (B) Difference analysis of TME-related scores between low and high WTAP expression groups. (C) Difference analysis of enrichment scores of immune-associated gene sets between low and high WTAP expression groups. (D) Differential expression analysis of chemokines between low and high WTAP expression groups. (E) The difference in immune infiltration level of TIICs between low and high WTAP expression groups in TCGA cohort. (F) Copy number variation of WTAP affects the infiltrating levels of CD4+ T cells, neutrophils, and dendritic cells. (G) Immunofluorescence staining of the nucleus, WTAP, and CD8 in four cases of GBM tissues. (H) Immunofluorescence staining of blood vessels and perivascular areas of GBM tissues. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001, ns, nonsense.