Research Paper Volume 16, Issue 6 pp 5601—5617
WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma
Figure 2. Further screening of RNA modification genes. (A) The scatterplot presented the eight kinds of cells with different colors in the TME of GBM based on the GSE84465 dataset. (B) The scatterplot presented the expression of WTAP in different types of cells. (C–H) The scatterplot presented the expression of FTO, ADAT2, NSUN6, RNMT, YTHDC2, and YTHDC1 in different types of cells. (I) Differential expression analysis of seven RNA modification genes between GBM tissues and NBTs. (J) The differential expression analysis of WTAP between GBM tissues and NBTs was performed in four independent GBM cohorts. (K) Western blot detection of the WTAP protein expression levels in paired GBM tissues and adjacent nontumor tissues. (L) Compared with adjacent nontumor tissues, WTAP protein expression was up-regulated in GBM tissues. *P < 0.05.