Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice

Yuyi Yuan; Shuangjiao Deng; Jia Yang; Zhexing Shou; Chunzhu Wei; Lijuan Zhang; Feng Zhu; Fei Gao; Xingxing Liu; Yujin Liu; Qianyun Chen; Heng Fan

doi:doi:10.18632/aging.205651

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Research Paper Volume 16, Issue 6 pp 5336—5353

Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice

Figure 3. miR-31-5p antagomir contributed to the damage of DSS to colon in mice. (A) Analysis of hematoxylin and eosin (HE) from colonic samples (x200 magnification). (B) DAI scores. (C) Colon lengths were presented. (D) Statistics of colon length. (E) Histological scores based on HE staining method. Each bar represents mean ± SD, n ≥ 3 from each group. ns represented P > 0.05, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001 vs. DSS group.