Figure 1.DOX inhibits collagen synthesis in cardiomyocytes and causes progressive thinning of the ventricular wall. (A) heat map of differential expressed collagen genes in the control group versus DOX group; (B) scatter plot of Reactome enrichment analysis of down regulated genes affected by DOX; (C) scan of heart tissue sections after HE staining; (D) statistical illustration of ventricular wall thickness and ventricular size in the control and DOX group. *P < 0.05 vs. the Control group, #P < 0.05 vs. the DOX group.
