Research Paper Volume 16, Issue 5 pp 4862—4888

Figure 6. Correlations between the LDCD-RGs score and tumor immune microenvironment in the 3 clusters. (A) The heat mapping demonstrated a correlation between immune-cell infiltration and LDCD. (B) The bubble plot underscored the interconnectedness of immune infiltration-associated cell types with LDCD. (C–F) The scatter plots illustrating the correlation analysis between LDCD-RGs scores and quantification of four types of immune cell infiltration (Treg cells, neutrophils, B cells, and dendritic cells). All four types of immune cells show a positive correlation with LDCD-RGs scores. (G) Heatmap showed the immune cell infiltration levels by TIMER, CIBERSORT, QUANTISEQ, and the MCPCOUNTER algorithm. (H) The box plots encompassed the examination of ICGs in 3 clusters. (^*p < 0.05; ^**p < 0.01; ^***p < 0.001; ^****p < 0.0001). Abbreviations: LDCD-RGs: LDCD-related genes; LDCD: Lysosomal-dependent cell death; ICGs: Immune checkpoint genes.