Research Paper Volume 16, Issue 6 pp 5184—5206
BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury
Figure 6. BMSCs-derived exosomes suppress macrophage/microglia pyroptosis after SCI by delivering miR-21a-5p. (A–E) Western blot detection and quantitative analysis of NLRP3, GSDMD, GSDMD-N, and p20 proteins in spinal cord tissue on the 7th day after injury; (F) Representative immunostaining image of IBA1 and GSDMD in mice of different groups on the 7th day after injury; (G) Quantification of fluorescence intensity; (H) Representative immunostaining image of IBA1 and Caspase-1 in mice of different groups on the 7th day after injury; (I) Quantification of fluorescence intensity (*p < 0.05, **p < 0.01,***p < 0.001).