Research Paper Volume 16, Issue 5 pp 4789—4810
SORBS1 inhibits epithelial to mesenchymal transition (EMT) of breast cancer cells by regulating PI3K/AKT signaling and macrophage phenotypic polarization
Figure 1. Relative expression of SORBS1 in breast cancer based on raw letter analysis. (A) The expression of SORBS1 mRNA in breast cancer and non-matched normal tissues based on the TCGA database, and the expression of SORBS1 mRNA in breast cancer tissues and adjacent tissues based on the GEO database. (B) The protein expression level of SORBS1 is based on CPTAC. (C) ROC curves of breast cancer and normal breast tissue classified in TCGA database. (D, E) Prognostic values of SORBS1 expression in patients with breast cancer evaluated by the Kaplan-Meier method. Overall survival and disease-specific survival (B) for breast cancer patients with high versus low SORBS1. (F) Representative images of SORBS1 protein expression in BRCA tissues and adjacent normal tissues. Original magnifications 200× and 400×. (G) Quantitative real-time PCR analysis of BRCA tissues and adjacent normal tissues. (*** P<0.001).