Research Perspective Volume 16, Issue 4 pp 3047—3055

Figure 1. Lifespan data for C57BL/6J male mice from multiple lifespan extension and other unrelated studies. Four sample “successful” lifespan extension studies are shown for comparison: the control data is in green and respective intervention data is depicted via the matching stroke (solid or broken) in red. Each colored curve is labeled with its plausibility score P. The PMIDs of sources used here are: 27549339 (rapamycin), 31773901 berberine, 17516143 curcumin and 34050173 SIRT6. ‘Meta-control’ data given in gray here are replotted and annotated in Supplementary Figure 1. EM - Extra Mortality test (see Supplementary Materials and Methods) was applied to datasets: V - passed, X - failed with the level of significance α = 0.01.