Research Paper Volume 16, Issue 5 pp 4469—4502
Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8
Figure 16. The role of MXRA8 in PC-3 cells and DU-145 cells. (A, B) After overexpression of MXRA8, the mRNA and protein levels of MXRA8 were up-regulated in PC3 cells; (C, D) After MXRA8 knockout, the RNA and protein expression of MXRA8 in DU-145 cells decreased; (E) After overexpression of MXRA8, the proliferation ability of PC-3 cells increased; (F) After knocking out MXRA8, the proliferation ability of DU-145 cells decreased; (G) After overexpression of MXRA8, the migration and invasion ability of PC-3 cells increased; (H) After knocking out MXRA8, the migration and invasion ability of DU-145 cells decreased.