Research Paper Volume 16, Issue 5 pp 4396—4422
A pair of primary colorectal cancer-derived and corresponding synchronous liver metastasis-derived organoid cell lines
Figure 3. Whole-exome sequencing (WES) and chromosome karyotype analysis of CWH22 and CLM22 organoids. (A) Overview of somatic mutations found in CRC/CLM tissues and CWH22/CLM22 organoids. (B) Histogram showing the concordance (percentage) of SNVs between CWH22/CLM22 organoids and corresponding CRC/CLM tissues. (C) The ordinate represents the multiple copy variations, the black line represents the multiple total copy number variations, and the red line represents the multiple minor copy number variations. When the value of the black line is >2, the copy number increases; when it is <2, the copy number decreases. (D, E) Chromosome karyotype pairing from one representative karyotype analysis and the chromosome numbers of 20 different metaphase cells of (D) CWH22 and (E) CLM22.