Research Paper Volume 16, Issue 5 pp 4327—4347

Figure 6. Influence of HPDL expression on anti-tumor immunity and immunotherapy response. (A) The Spearman correlation heatmap shows the correlation between the expression of HPDL and 47 kinds of immune regulators in pan-cancer. Red represents positive correlation and blue represents negative correlation. (B) The correlation between HPDL expression and the ENHsi, DMPsi, EREG-mDNAsi, mDNAsi, EREG-mRNAsi, and mRNAsi. (C) Kaplan-Meier curve of low and high-HPDL subgroup in IMvigor210 cohort (anti-PD-L1), and the proportion of tumors (including kidney cancer) in the low-HPDL and high-HPDL subgroups in the IMvigor210 cohort who responded to PD-1 therapy. (D) Kaplan-Meier curve of GSE78220 (anti-PD-1 melanoma) in the low and high-HPDL patient groups, and the proportion of melanoma patients in the GSE78220 low and high-HPDL subgroups that responded to anti-PD-1 therapy. (E, F) The correlation between HPDL expression and the TMB (E), and MSI (F). The labelled asterisk indicated the statistical p-value (^*p < 0.05, ^**p < 0.01, ^***p < 0.001).