Research Paper Volume 16, Issue 4 pp 3934—3954
Functional enrichment analysis reveals the involvement of DARS2 in multiple biological pathways and its potential as a therapeutic target in esophageal carcinoma
Figure 1. Bioinformatics analysis of DARS2 expression. (A) The expression level of DARS2 was assessed by analyzing the TCGA-GTEx pan-cancer datasets. (B) In the TCGA ESCA dataset, the differential expression of DARS2 between cancer samples and paired normal samples. (C) Cell experiments evaluated differences in DARS2 expression. (D–F) The variation in DARS2 expression was investigated between ESCA cancer tissue and normal tissue in the GSE20347, GSE38129, and GSE45670 datasets. (G) Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the utility of DARS2 as a diagnostic marker for ESCA. *p < 0.05; **p < 0.01; ***p < 0.001; ns, no significance.